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Recent publications authored or co-authored by Dr. MacCoss (of 167 in total)

posted Jul 18, 2012, 6:31 PM by Malcolm MacCoss   [ updated Jun 5, 2019, 10:43 AM ]

Carroll, S.S., Koeplinger, K., Vavrek, M., Zhang, N.R., Handt, L., MacCoss, M., Olsen, D.B., Reddy, K.R., Sun, Z., van Poelje, P.D., Fujitaki, J.M., Boyer, S.H., Linemeyer, D.L., Hecker, S.J., and Erion, M.D.  Antiviral efficacy upon administration of a HepDirect prodrug of 2’-C-methylcytidine to Hepatitis C virus-infected chimpanzees.  Antimicrobial Agents and Chemotherapy, 55: 3854 (2011)


Sun, Z.Y., Asberom, T., Bara, T., Bennett, C., Burnett, D.A., Chou, I., Clader, J., Cohen-Williams, M., Cole, D., Czarniecki, M., Durkin, J., Gallo, G., Greenlee, W.J., Josien, H., Huang, X., Hyde, L., Jones, N., Kazakevich, I., Li, H., Liu, X., Lee, J., MacCoss, M., McCracken, T., Nomeir, A., Mazzola, R., Palani, A., Parker, E.M., Pissarnitski, D., Qin, J., Song, L., Terracina, G., Vicarel, M., Voigt, J.H., Xu, R., Zhang, L., Zhang, Q., Zhao, Z., Zhu, X., and Zhu, Z.  Cyclic hydroxyamidines as amide isosteres:  Discovery of oxadiazolines and oxadiazines as potent and highly efficacious g-secretase modulators in vivo.  J. Med. Chem., 55: 489 (2012)


Huang, Y., Bennett, F., Verma, V., Njoroge, F.G., and MacCoss, M.  A notable conversion of a thioacetate to it’s corresponding sulfonyl chloride.  Tetrahedron Letters, 53: 3203 (2012)


Arasappan, A., Bennett, F., Girijavallabhan, V., Huang, Y., Huelgas, R.,Alvarez, C., Chen, L., Gavalas, S., Kim, S-H., Kosinski, A., Pinto, P., Rizvi, R., Rossman, R., Shankar, B., Tong, L., Velazquez, F., Venkatraman, S., Kozlowski, J., Shih, N-Y., Piwinski, J.J., MacCoss, M., Kwong, C.D., Clark, J.L., Fowler, A.T., Geng, F., Kezar III, H.S., Roychowdhury, A., Reynolds, R.C., Maddry, J.A., Ananthan, S., Secrist III, J.A., Cheng, L., Chase, R., Curry, S., Huang, H-C., Tong, X. and Njoroge, G.  5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.  Bioorganic & Med. Chem. Letters, 22: 3229 (2012)


Bennett, F., Kezar III, H.S., Girijavallabhan, V., Huang, Y., Huelgas, R., Rossman, R., Shih, N-Y., Piwinski, J.J., MacCoss, M., Kwong, C.D., Clark, J.L., Fowler, A.T., Geng, F., Roychowdhury, A., Reynolds, R.C., Maddry, J.A., Ananthan, S., Secrist III, J.A., Li, C., Chase, R., Curry, S., Huang, H-C., Tong, X., Njoroge, G. and Arasappan, A.  Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.  Bioorganic & Med. Chem. Letters, 22: 5144 (2012)


Girijavallabhan, V., Alvarez, C., Bennett, F., Chen, L., Gavalas, S., Huang, Y., Kim, S-H., Kosinski, A., Pinto, P., Rizvi, R., Rossman, R., Shankar, B., Tong, L., Velazquez, F., Venkatraman, S., Verma, V.A., Kozlowski, J., Shih, N-Y., Piwinski, J.J., MacCoss, M., Kwong, C.D., Bansal, N., Clark, J.L., Fowler, A.T., Kezar III, H.S., Valiyaveettil, J., Reynolds, R.C., Maddry, J.A., Ananthan, S., Secrist III, J.A., Cheng, L., Chase, R., Curry, S., Huang, H-C., Tong, X., Njoroge, G. and Arasappan, A.  Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.  Bioorganic & Med. Chem. Letters, 22: 5652 (2012)


Verma, V.A., Rossman, R., Bennett, F., Chen, L., Gavalas, S., Girijavallabhan, V., Huang, Y., Kim, S-H., Kosinski, A., Pinto, P., Rizvi, R., Shankar, B., Tong, L., Velazquez, F., Venkatraman, S., Kozlowski, J., MacCoss, M., Kwong, C.D., Bansal, N., Kezar III, H.S., Reynolds, R.C., Maddry, J.A., Ananthan, S., Secrist III, J.A., Cheng, L., Chase, R., Curry, S., Huang, H-C., Tong, X., Njoroge, G. and Arasappan, A.  Synthesis and SAR of germinal substitutions at the C5’ carbosugar position of pyrimidine-derived HCV inhibitors.  Bioorganic & Med. Chem. Letters, 22: 6967 (2012).


M. MacCoss, “Introduction: Drug Discovery in Difficult Times” in “Case Studies in Modern Drug Discovery and Development”, editors: Xianhai Huang and Robert Aslanian, John Wiley & Sons, Inc, Hoboken, NJ, 2012.


M. MacCoss, “A Career in Medicinal Chemistry - A Journey in Drug Discovery“, Annual Reports in Medicinal Chemistry, 23-34, 48, 2013.


Taylor, R., MacCoss, M. and Lawson, A.  Rings in drugs.  J. Med. Chem., 57: 5845 (2014)

Taylor, R., MacCoss, M. and Lawson, A.  Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug DiscoveryJ. Med. Chem., 60: 1638 (2016)

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Elbert, B.L., Farley, A.J.M., Gorman, T.W., Johnson, T.C., Genicot, C., Lallemand, B., Pasau, P., Flasz, J., Castro, L., MacCoss, M., Paton, R., Schofield, C.J., Smith, M.D., and Dixon, D.J., Willis, M.C.  A General C-H Cyanation of 6-Ring N-containing Heteroaromatics.  Chemistry – a European J., 23: 14,733 (2017).

 Johnson, T.C., Elbert, B.L., Farley, A.J.M., Gorman, Genicot, C., T.W., Lallemand, B., Pasau, P., Flasz, J., Castro, L., MacCoss, M., Dixon, D.J.,  Paton, R., Schofield, C.J., Smith, M.D., and Willis, M.C.  Direct Sulphonylation of Anilines Mediated by Visible Light.  Chemical Science, 9: 629 (2018).

 Lawson, A.D.G., MacCoss, M., and Heer, J.P.  On the Importance of Rigidity in Designing Small Molecules to Tackle the Problem of Inhibution of Protein-Protein Interactions (PPIs).  J. Med. Chem., 61: 4283 (2018) 

 

 


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